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全血中 10 种微量元素水平与老年人 3 种肥胖风险的关联

发布时间:2024-01-04 16:44 作者:rkjkys 浏览:
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Associations of 10 trace element levels in the whole blood with risk of three types of obesity in the elderly

 全血中 10 种微量元素水平与老年人 3 种肥胖风险的关联

 

Authors: Rui ZhanLin LiuMaoyuan YangYating RenZhihao GeJun ShiKe ZhouJiebao ZhangHongjuan CaoLinsheng YangKaiyong LiuJie ShengFangbiao Tao & Sufang Wang

 

Source:Environ Geochem Health (2023) 45:9787–9806

Doi: 10.1007/s10653-023-01747-w

 

Abstract

Background

Currently, over 2 billion people worldwide suffer from obesity, which poses a serious health risk. More and more attention is being given to the effects of trace elements on obesity in recent years. Synergistic or antagonistic interactions among these elements can adversely or positively impact human health. However, epidemiological evidence on the relationship between trace element exposure levels and obesity has been inconclusive.

Methods

Baseline data of 994 participants from the Cohort of Elderly Health and Environment Controllable Factors were used in the present study. ICP-MS was used to measure the concentrations of 10 trace elements in the whole blood of the older population. Binary logistic regression, restricted cubic splines (RCS) models, and Bayesian kernel machine regression (BKMR) models were employed to assess single, nonlinear, and mixed relationships between 10 trace element levels and three types of obesity based on body mass index (BMI), waist circumference (WC), and body fat percentage (BFP) in the elderly.

Results

Based on BMI, WC and BFP, 51.8% of the included old population were defined as general overweight/obesity, 67.1% as abdominal obesity, and 36.2% as having slightly high/high BFP. After multivariable adjustment, compared with the lowest tertile, the highest tertile of blood selenium (Se) concentration was associated with an increased risk of all three types of obesity. Additionally, compared with the lowest tertile, higher tertiles of strontium (Sr) concentrations were associated with a lower risk of general overweight/obesity and having slightly high/high BFP, and the highest tertile of barium (Ba) was associated with a lower risk of having slightly high BFP, while higher tertiles of arsenic (As) concentrations were associated with an increased risk of having slightly high/high BFP, and the highest tertile of manganese (Mn) was associated with a higher risk of abdominal obesity. BKMR analyses showed a strong linear positive association between Se and three types of obesity. Higher blood levels of trace element mixture were associated with increased obesity risks in a dose–response pattern, with Se having the highest value of the posterior inclusion probability (PIP) within the mixture.

Conclusions

In this study, we found higher Se levels were associated with an elevated risk of obesity and high levels of Ba, Pb and Cr were associated with a decreased risk of obesity. Studies with larger samples are needed to confirm these findings.

 

背景

目前,全球有超过20亿人患有肥胖症,这构成了严重的健康风险。近年来,微量元素对肥胖的影响越来越受到关注。这些元素之间的协同或拮抗相互作用会对人类健康产生不利影响或积极影响。然而,关于微量元素暴露水平与肥胖之间关系的流行病学证据尚无定论。

方法

本研究使用了来自老年人健康和环境可控因素队列的 994 名参与者的基线数据。采用ICP-MS检测老年人全血中10种微量元素的浓度。采用二元logistic回归、受限三次样条(RCS)模型和贝叶斯核机回归(BKMR)模型,根据体重指数(BMI)、腰围(WC)和体脂率(BFP)评估10种微量元素水平与3种肥胖之间的单一、非线性和混合关系。

结果

根据 BMI、WC 和 BFP,51.8% 的纳入老年人群被定义为一般超重/肥胖,67.1% 被定义为腹部肥胖,36.2% 被定义为轻高/高 BFP。经多变量调整后,与最低三分位数相比,血硒(Se)浓度的最高三分位数与所有三种肥胖风险的增加相关。此外,与最低的三分位数相比,较高的三分位数的锶 (Sr) 浓度与较低的一般超重/肥胖风险和略高/高的 BFP 相关,而最高三分位数的钡 (Ba) 与较低的 BFP 略高风险相关,而较高的三分位数的砷 (As) 浓度与略高/高 BFP 的风险增加相关, 锰(Mn)的最高三分位数与腹部肥胖的风险较高有关。BKMR分析显示,硒与三种肥胖之间存在很强的线性正相关。血液中微量元素混合物的较高水平与剂量反应模式中的肥胖风险增加有关,其中 Se 在混合物中的后部包涵概率 (PIP) 值最高。

结论

在这项研究中,我们发现较高的硒水平与肥胖风险升高有关,高水平的 Ba、Pb 和 Cr 与肥胖风险降低有关。需要对更大样本进行研究来证实这些发现。

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